26-year-old Victoria Scott was sentenced last year for stabbing Edwin Littlefield to death in a fight that occurred in Waldo back in 2017.
Scott's defense attorneys claimed she acted in self-defense, but prosecutors say she aggressively confronted him.
Jurors found Scott guilty and she was sentenced to serve 11 years in prison.
In the appeal, Scott's legal representatives challenged testimony from two witnesses, statements made by the state during its closing arguments, the sufficiency of evidence and other factors in the case, all of which they say compromised Scott's right to a fair trial.
The majority of the state Supreme Judicial Court Justices denied the appeal and upheld the conviction.
However, Justice Joseph Jabar wrote a dissenting opinion, saying he believes Scott did not get a fair trial and her conviction should be vacated.