Crews were called to the mobile home on Route 1 around noon on Friday.
Officials said one man was home inside a rear bedroom with the door closed.
Authorities said by the time he noticed smoke and opened the door he couldn't get out and had to escape through a bedroom window.
Several towns were called to assist with the fire.
Officials said they suspect it may have been caused by an overloaded electrical strip.
The Red Cross is helping the family.